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<p><img style="display: block; margin-left: auto; margin-right: auto;" src="https://first-fish.oss-us-west-1.aliyuncs.com/file/2/eto-sterilization-vs.-other-methods.webp" alt="ETO Sterilization vs. Other Methods.webp" width="800"></p>
<p>There are many methods of sterilization. One commonly used method is Ethylene Oxide (ETO) sterilization. Let me show you the difference between ETO sterilization with other sterilization techniques.</p>
<p>&nbsp;</p>
<h2>(1) <strong>Steam Sterilization (Autoclave):</strong></h2>
<p>Steam sterilization uses high-pressure steam to kill microorganisms.</p>
<h3>Advantages</h3>
<p>&bull; Nontoxic to patient, staff, and environment</p>
<p>&bull; Cycle easy to control and monitor</p>
<p>&bull; Rapidly microbicidal</p>
<p>&bull; Least affected by organic/inorganic soils among sterilization processes listed</p>
<p>&bull; Rapid cycle time</p>
<p>&bull; Penetrates medical packing, device lumens</p>
<p>&bull; Long history of safe and effective</p>
<h3>Disadvantages</h3>
<p>&bull; Deleterious for heat-sensitive instruments/devices</p>
<p>&bull; Microsurgical instruments damaged by repeated exposure</p>
<p>&bull; May leave instruments wet</p>
<p>&bull; causing them to rust</p>
<p>&bull; Potential for burns</p>
<p>&bull; Not compatible with most medical devices because plastics heat sensitive</p>
<p>&nbsp;</p>
<h2>(2)Gas Plasma Sterilization:</h2>
<p>Gas plasma sterilization uses low-temperature hydrogen peroxide gas plasma to sterilize medical instruments. It is a low-temperature process that is safe for heat-sensitive materials.</p>
<h3>Advantages</h3>
<p>&bull; It was a safe way for the environment</p>
<p>&bull; Leaves no toxic residuals</p>
<p>&bull; Cycle time is &lt;70 minutes and no aeration necessary</p>
<p>&bull; Used for heat- and moisture-sensitive items since process temperature &lt;50oC</p>
<p>&bull; Simple to operate, install (208 V outlet), and monitor</p>
<p>&bull; Compatible with most medical devices</p>
<p>&bull; Only requires an electrical outlet</p>
<p>&bull; Microbicidal efficacy data</p>
<p>&bull; Able to sterilize electronic components and batteries</p>
<h3>Disadvantages</h3>
<p>&bull; Cellulose (paper), linens, and liquids cannot be processed</p>
<p>&bull; Very few single-use medical devices (34) have been validated</p>
<p>&bull; Sensitive to small changes in process parameters</p>
<p>&bull; Restrictions based on lumen internal diameter and length (see manufacturer&rsquo;s recommendations)</p>
<p>&bull; Requires synthetic packaging (polypropylene wraps, polyolefin pouches) and special container tray</p>
<p>&bull; Scalability or chamber size challenging</p>
<p>&bull; Hydrogen peroxide may be toxic at levels greater than 1 ppm TWA</p>
<p>&nbsp;</p>
<h2>(3) <strong>Dry Heat Sterilization</strong></h2>
<p>:</p>
<p>Dry heat sterilization uses hot air to sterilize items. &nbsp;It is suitable for heat-stable materials and can penetrate porous items effectively. &nbsp;</p>
<p>The greatest problem with sterilization by dry heat is that the sterilization process is slow. Thus, dry heat sterilization can only sterilize items capable of holding their integrity at high heat for long periods. Additionally, the dry heat sterilization process is difficult to control within precise temperature limits, which is why the USP states that an acceptable operating temperature range for the empty chamber is &plusmn; 15℃.</p>
<p>&nbsp;</p>
<h2>(4) Radiation (Gamma, X-Ray, Electron beam):</h2>
<p>Irradiation uses high-energy gamma rays to kill microorganisms. It can penetrate through packaging materials and is suitable for a wide range of products. &nbsp;</p>
<h3>Advantages</h3>
<p>&bull; Compatible with many medical materials</p>
<p>&bull; Products can be processed in sealed, final packaging</p>
<p>&bull; Penetrates medical packaging</p>
<p>&bull; Microbicidal data</p>
<p>&bull; Long history of safe and effective use</p>
<p>&bull; No residue on sterilized products</p>
<p>&bull; No regulated emission</p>
<h3>Disadvantages</h3>
<p>&bull; Individual plastics need to be assessed</p>
<p>&bull; Common plastics (Teflon, PFA, PTFE, PP) must be avoided</p>
<p>&bull; Adverse effects on glues and adhesives</p>
<p>&bull; Gamma requires a nuclear reactor, expensive</p>
<p>&bull; Source replenishment and requalification required (Cobalt-60)</p>
<p>&bull; Licensing, installation, security, waste disposal challenging</p>
<p>&bull; E-beam limited penetrating power</p>
<p>&nbsp;</p>
<h2>(5) Chemical Sterilization:</h2>
<p>Chemical sterilization techniques, such as Nitrogen dioxide or chlorine dioxide gas, involve the use of sterilizing chemicals. &nbsp;</p>
<h3>1. Nitrogen dioxide</h3>
<h4>Advantages</h4>
<p>&bull; Used for heat-sensitive items</p>
<p>&bull; Compatible with most plastics</p>
<p>&bull; Potential for in-house sterilization</p>
<p>&bull; No cytotoxic residues</p>
<h4>Disadvantages</h4>
<p>&bull; Poor penetration power; can penetrate primary packaging but not end package</p>
<p>&bull; Not compatible with cardboard</p>
<p>&bull; Limited experience, must be evaluated for compatibility, product performance, residuals,</p>
<p>microbial efficacy, scalability</p>
<p>&bull; Little or no published information</p>
<p>&bull; Very few single-use medical devices (7) validated</p>
<p>&bull; FDA not determined to be adequate</p>
<p>&bull; Surface sterilant (does not penetrate)</p>
<h3>2. Chlorine dioxide</h3>
<h4>Advantages</h4>
<p>&bull; Used for heat-sensitive items</p>
<p>&bull; Primary use for chlorine dioxide is room decontamination</p>
<p>&bull; Does not damage electronics and batteries</p>
<p>&bull; Rapid aeration</p>
<h4>Disadvantages</h4>
<p>&bull; Poor penetration power; can penetrate primary packaging but not end package</p>
<p>&bull; Not compatible with cardboard</p>
<p>&bull; Limited experience, must be evaluated for compatibility, product performance, residuals, microbial efficacy, scalability</p>
<p>&bull; Little or no published information</p>
<p>&bull; Very few single-use medical devices (7) validated</p>
<p>&bull; FDA not determined to be adequate</p>
<p>&bull; Surface sterilant (does not penetrate)</p>
<p>&nbsp;</p>
<h2>(6)<a href="https://www.hzbocon.com/product-list/ethylene-oxide-sterilizer"> ETO Sterilization</a></h2>
<p>ETO sterilization involves exposing items to ethylene oxide gas. &nbsp;It is a low-temperature process and is effective for heat-sensitive materials and complex instruments. &nbsp;</p>
<h3>Advantages</h3>
<p>&bull; Penetrates packaging materials, device lumens</p>
<p>&bull; Best materials compatibility</p>
<p>&bull; Products can be processed in sealed, final packaging</p>
<p>&bull; About 50,000 medical devices validated</p>
<p>&bull; Simple to operate and monitor</p>
<p>&bull; Can sterilize products with batteries and electronics</p>
<p>&bull; Long history of safe and effective use</p>
<p>&bull; Broad microbicidal activity</p>
<h3>Disadvantages</h3>
<p>&bull; Requires aeration time to remove ETO residue</p>
<p>&bull; ETO is toxic, a carcinogen, and flammable</p>
<p>&bull; ETO 1ppm TWA employee exposure</p>
<p>&bull; Lengthy cycle/aeration time</p>
<p>&nbsp;</p>

ETO Sterilization Vs. Other Methods: A Comparison Of Sterilization Techniques

Publish Time：2023-10-11